Do You Know All The Basics Of Flash Column?


Flash column is a cost-effective technique to separate mixtures of molecules into their individual constituents, and it is more frequently used in the drug discovery process. It is able to separate substances based on differential adsorption of compounds to the adsorbent; compounds move through the column at different rates, allowing them to be separated into fractions.


The principal behind flash column is simple-due to their particular chemistry-polarity differences, compounds in solution will separate from each other, given the right conditions and technique. These chemical differences are based on each compound’s solubility in a particular solvent. Compounds with lower solubility can be removed from those with greater solubility using the same solvent.

Separation process

To separate, it uses a column filled with a pure, solid medium such as synthetic silica onto which the chemical mixture is introduced. The solvent is introduced into the column by a pump after the mixture is added to the top of the column. Those compounds that have higher solubility will migrate through the column faster than those with less solubility and can be collected individually. The collected materials will be purer than before.

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