Fillers of Flash Column
Developed as a modification of preparative column chromatography in the past few decades, flash chromatography is an air pressure-driven technique to gain the rapid separations of organic compounds in the lab. It is approved as a simple, fast, and economical approach to preparative liquid chromatography for chemical species’ purification.
The flash chromatography system consists of a prepacked plastic cartridge, and the solvent is pumped through the cartridges to achieve separation. You can link the flash column system with the detectors and fraction collectors. And the system can even be automated if you want.
With the full line of different sizes, Hawach always provides you with a high-purity stationary phased-packed flash column. Such as Spherical SCX Flash Column, Spherical C8 Flash Column. And the column cartridge made from medical grade virgin PP and PE materials and different stationary phases prepacked will help you to meet a variety of compounds analysis of various properties from hydrophilic to hydrophobic, such as polar, semi-polar, and non-polar compounds.
Types of Fillers
The fillers of the Hawach flash column comprise Al2O3, polymer matrix, and silica gel matrix. Each of them has its own advantages and disadvantages, and the following passage presents a brief introduction to them.
1. Al2O3 matrix
Advantages: the stability is good, and the PH is 1 ≤ 14.
Disadvantages: chemical modification is difficult.
2. Polymer matrix
Advantages: the stability is good, and PH is 1 ≤ 13; surface chemical treatment can be carried out to meet the needs of reversed-phase chromatography, ion-exchange chromatography, hydrophobic interaction chromatography, and volume exclusion chromatography.
Disadvantages: the pore size structure is complex and the pore size is not uniform, resulting in the column effect is not high enough.