The Importance of Flash Columns in Chromatography

The rapid chromatographic method is a technology widely used in the isolation and clarification of active target compounds, such as organic compounds, inartificial products, and biomacromolecule. The rapid chromatographic method is easy to operate, low-price, and fast-analysis. In the application of purifying organic compounds, there is almost no other technology that is better than the rapid chromatographic method. The rapid chromatographic method is a typical low-pressure technology. The flash column is full of silica gel, adsorbent with a grain size of 40-60 um. The smaller particle size is suitable for the low-viscosity mobile phase.

Rapid chromatography is often used in TLC. The demand for rapid chromatography mainly comes from the pharmaceutical industry, biotechnology, and academic institutions, which occupy 84% of the market share of rapid chromatography. In the pharmaceutical industry, rapid chromatography is widely used, including the purification of a small number of compounds, polypeptides, and natural products.

In the process of chromatographic analysis, a flash liquid chromatographic column with high separation performance and stability plays a key role in establishing a reliable separation and purification process. A rapid chromatographic column with high separation performance can ensure maximum separation of target compounds and impurities.

The uniform distribution of the packing size in the flash columns ensures the normal column pressure when using. Manufacturers will test many times with precise regulations when making the flash column to ensure high recovery and perfect reproducibility of chromatographic columns and separate the target compounds effectively.

Invented by Professor Clark Still of Columbia University several years ago, flash chromatography was popularized nowadays. To replace the slow and inefficient gravity-fed chromatography, flash chromatography works differently from the old ways.

Slightly smaller silica gel particles are used, and the pressurized gas is used to drive the solvent through the column of stationary phase because the restricted solvent flow is caused by the small gel particles in practice. Due to these two innovation, we can get a high efficient resolution chromatography.

You can always find Hawach flash columns with special high purity stationary phased packed with the full range of sizes. With the cartridge made from medical grade virgin PP material and PE frits.

From hydrophilic to hydrophobic, Hawach offers excellent separation performance flash columns for compounds analysis of a varies of properties. And the stationary phase includes Standard Silica gel flash columns, Superior Silica gel flash columns, Spherical C18 flash columns, Irregular C18, Spherical NH2, Spherical C4 flash columns, Spherical C8, Spherical CN, Spherical HILIC, Neutral Alumina, Spherical Phenyl, Spherical SAX flash columns, Spherical SCX, Spherical C8, Spherical Diol, etc..